Posted by Jay2112 on February 21, 2022, at 12:53:09
In reply to Re: Anyone try CBD?, posted by undopaminergic on February 21, 2022, at 8:01:04
> > CBD is pleiotropic (multiple mechanisms) and the mechanism is not completely understood. However some of the known mechanisms include:
> >
> > -5-ht1a agonism (moderate)
> > -d2 presynaptic agonist (like abilify)
> > -gaba-a positive modulator
> > -indirect sodium channel antagonist
> > -TRVP-1 agonist (anticonvulsant/analgesic effects)
> > -inhibits anandamide metabolism by inhibiting fatty acid binding proteins
> > - not a direct cb1/cb2 agonist, but may indirectly increase receptor activity
> > -anti-inflammatory effect
> >
>
> Wikipedia mentions:
> - allosteric modulation of mu- and delta-opioid receptors
>
> Wikipedia also mentions: Cannabidiol has low affinity for the cannabinoid CB1 and CB2 receptors, although it can act as an antagonist of CB1/CB2 agonists despite this low affinity.
>
> -undopaminergic
>I think that a big point of contention, that I have heard a number of researchers bring up, though, is the *strength* and efficacy of CBD that is required to produce a noticeable effect in all of the mentioned areas. I have read (this is not *my* opinion) some researchers say that CBD is of very little value without some THC. Like any drug, it is also very, very much divergent based on so many genetic variables.
Like many early researchers did, the only real way to find it's value is to take some yourself...and adjust doses as needed. Seriously, like Albert Hoffman and LSD. (Maybe you'll get lucky to have such a great experience...eerr..trip, too :)
Jay
Humans punish themselves endlessly
for not being what they believe they should be.
-Don Miguel Ruiz-
poster:Jay2112
thread:1118679
URL: http://www.dr-bob.org/babble/20220128/msgs/1118708.html