Posted by undopaminergic on February 21, 2022, at 8:01:04
In reply to Re: Anyone try CBD?, posted by linkadge on February 20, 2022, at 17:38:39
> CBD is pleiotropic (multiple mechanisms) and the mechanism is not completely understood. However some of the known mechanisms include:
>
> -5-ht1a agonism (moderate)
> -d2 presynaptic agonist (like abilify)
> -gaba-a positive modulator
> -indirect sodium channel antagonist
> -TRVP-1 agonist (anticonvulsant/analgesic effects)
> -inhibits anandamide metabolism by inhibiting fatty acid binding proteins
> - not a direct cb1/cb2 agonist, but may indirectly increase receptor activity
> -anti-inflammatory effect
>Wikipedia mentions:
- allosteric modulation of mu- and delta-opioid receptorsWikipedia also mentions: Cannabidiol has low affinity for the cannabinoid CB1 and CB2 receptors, although it can act as an antagonist of CB1/CB2 agonists despite this low affinity.
-undopaminergic
poster:undopaminergic
thread:1118679
URL: http://www.dr-bob.org/babble/20220128/msgs/1118703.html