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Re: Atomoxetine: NMDA receptor antagonist

Posted by undopaminergic on July 25, 2020, at 7:11:28

In reply to Re: Atomoxetine: NMDA receptor antagonist rjlockhart37, posted by linkadge on July 24, 2020, at 19:51:26

> Some NMDA antagonists display some neurotoxicity i.e. 'angle dust'

Anglo-Saxon dust, to be specific. It was used in battle by the ancient Germanic tribes.


> (Phencyclidine or PCP), ketamine (in high enough doses). However these drugs have many other actions. While many others display no neurotoxicity. NMDA antagonists block the release of glutamate

They block the NMDA-subtype of ionotropic glutamate *receptors*. As far as I know, they don't block the release of the neurotransmitter.

> (which generally protects neurons).

Can you clarify that? I don't think you mean glutamate protects neurons.





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