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Re: Atomoxetine: NMDA receptor antagonist

Posted by undopaminergic on July 25, 2020, at 5:54:37

In reply to Atomoxetine: NMDA receptor antagonist, posted by NKP on July 23, 2020, at 3:16:56

> Apart from its primary effect of being a norepinephrine reuptake inhibitor, atomoxetine is also a mild NMDA receptor antagonist.
> To my knowledge, NMDA receptor antagonists are neurotoxic.

It's known as "Olney's lesions". Many NMDA-antagonists can cause it, but there are at least some exceptions, including memantine and xenon. I don't know about nitrous oxide.

> Is atomoxetine neurotoxic, or is it a case of dose maketh poison?

Yes, I'm pretty certain you'd have to take megadoses for this action to be significant. I don't know about the kappa-opioid effect it also has, but personally I would be more concerned about that.





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