Posted by undopaminergic on July 25, 2020, at 5:54:37
In reply to Atomoxetine: NMDA receptor antagonist, posted by NKP on July 23, 2020, at 3:16:56
> Apart from its primary effect of being a norepinephrine reuptake inhibitor, atomoxetine is also a mild NMDA receptor antagonist.
>
> To my knowledge, NMDA receptor antagonists are neurotoxic.It's known as "Olney's lesions". Many NMDA-antagonists can cause it, but there are at least some exceptions, including memantine and xenon. I don't know about nitrous oxide.
> Is atomoxetine neurotoxic, or is it a case of dose maketh poison?
Yes, I'm pretty certain you'd have to take megadoses for this action to be significant. I don't know about the kappa-opioid effect it also has, but personally I would be more concerned about that.
-undopaminergic
poster:undopaminergic
thread:1111340
URL: http://www.dr-bob.org/babble/20200711/msgs/1111367.html