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Re: Atomoxetine: NMDA receptor antagonist

Posted by undopaminergic on July 27, 2020, at 10:49:22

In reply to Re: Atomoxetine: NMDA receptor antagonist NKP, posted by linkadge on July 27, 2020, at 9:28:59

> Yes, norepinephrine (in general) activates growth / protective factors in the brain (like nerve growth factor NGF and brain derived neurotrophic factor).

One major problem with adrenergics is the vascular effects. People have strokes and ischaemic heart attacks from cocaine. Not sure whether cocaine is a more potent NRI than atomoxetine.

> A few other things to keep in mind
> 1) Even if atomoxetine had some toxicity, tolerance to this effect may occur over time. For example, in rats you can prevent many of the the neurotoxic effects of high dise methamphetamine simply by increasing the dose more slowly.

Thanks, I found that useful.

> For example, since starting atomoxetine, my sleep has improved quite a bit.

That is peculiar. I had early awakenings from reboxetine. It seemed I didn't sleep as deeply.





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