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Re: Atomoxetine: NMDA receptor antagonist rjlockhart37

Posted by linkadge on July 24, 2020, at 19:51:26

In reply to Re: Atomoxetine: NMDA receptor antagonist, posted by rjlockhart37 on July 23, 2020, at 17:38:50

Short answer ... NMDA antagonists not neurotoxic as a class.

For example, magnesium is a NMDA antagonist (and is highly neuroprotective at the right dose) zinc is also and NMDA antagonist.

Some NMDA antagonists display some neurotoxicity i.e. 'angle dust' (Phencyclidine or PCP), ketamine (in high enough doses). However these drugs have many other actions. While many others display no neurotoxicity. NMDA antagonists block the release of glutamate (which generally protects neurons). However, at very high doses, some of these drugs start to do the reverse - i.e. activate glutamate. It's complex and I don't completely understand it all myself.

As for atomoxetine, it is only a weak NMDA antagonist. Also, it acts at the same site as magnesium (meaning it is as harmless as magnesium). If anything, this action is neuroprotective.

Linkadge


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