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Re: Norepinehprine D4 receptor linkadge

Posted by undopaminergic on June 2, 2020, at 2:45:32

In reply to Re: Norepinehprine D4 receptor undopaminergic, posted by linkadge on June 1, 2020, at 10:56:31

> Hmm.
>
> I remember reading somewhere that kappa agonists increased GDNF (a substances that apparently reduces additive like behaviors). I think that salvia has some agonist activity at d2 as well (have to look). Anyhow, I didn't mind salvia during the effect. I had some mild-moderate visual distortions and a loss of self-other boundaries. You could say that it induced some dysphoria, but it also felt like it had some mood stabilizing properties.
>

Salvia has quite a short duration of action, as far as I can recall, so how did you come up with the hypothesis that it may be mood-stabilising?

> There was a reduction in color perception (which rebounded after the effect wore off).
>

I feel I have a reduction of colour perception all the time, and pramipexole temporarily restored it to normal.

> Anything that kills my ego helps my depression. (not my ego in the 'personality' sense, but my ego in the sense of hyperawareness of my own consciousness and mortality...how everything must be analyzed in a self-referential way). I like things that let me fade into the woodwork feeling part of something bigger without having to be bigger myself).
>

I suggest you look into Buddhist meditation. It is big on the idea of overcoming what they call "duality" (the duality of self and other).

> I suppose that antipsychotics can kill the ego as well, but I found they just induced feelings of worthlessness --- rather than self disappearance.
>

I have never experienced any loss of ego with antipsychotics, but I feel they may stimulate objectivity in thinking.

> When I am suicidal its just that I want to stop feeling my consciousness. I want to be dead (in a sense) yet still be alive if that makes any sense. I crave drugs that make me feel disconnected yet still alive. Alive enough to live but not so alive to incessantly ruminate about my first world problems.
>

Kappa agonists can make you feel disconnected, or detached. Or at least depersonalisation can, like you are an observer of life rather than a participant. This can be nice temporarily for coping.

Based on my own experience, I would suggest that stimulants can get rid of suicidal ideation, but you already tried that. Based on what I've read, lithium is also anti-suicidal.

-undopaminergic


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