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Re: Norepinehprine D4 receptor undopaminergic

Posted by linkadge on June 1, 2020, at 5:29:40

In reply to Re: Norepinehprine D4 receptor, posted by undopaminergic on June 1, 2020, at 3:14:20

>atomoxetine is a kappa opioid receptor antagonist

Clarification - I believe it is an **agonist at the kappa receptor. Kappa agonism can cause dysphoria, which my be why atomoxetine failed as an antidepressant. Kappa antagonists (mirtazapine is a weak antagonist) have antidepressant properties. Dynorphin (a kappa agonist) is increased by stress and may be related to stress induced depression.

You're right that kappa agonists can produce depersonalization (akin to the drug salvorin-a in salvia). I actually liked salvia. There is some evidence that kappa agonists have anticonvulsant and anti-addictive properties.

Linkadge


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URL: http://www.dr-bob.org/babble/20200511/msgs/1110431.html