Re: Norepinehprine D4 receptor

Posted by undopaminergic on May 29, 2020, at 11:05:18

In reply to Norepinehprine D4 receptor, posted by linkadge on May 28, 2020, at 7:44:50

> Apparently norepinephrine itself is a potent activator of dopamine d4 receptors. D4 receptors have been implicated in ADHD. I wonder if this is behind the efficacy of NRIs in ADHD.
>
> https://pubmed.ncbi.nlm.nih.gov/9042615/
>
> Linkadge
Cite: "... noradrenaline and adrenaline exhibited a high affinity binding component (KH = 12.1 nM and 5.0 nM, respectively), similar to that of dopamine (KH = 2.6 nM), ...", and: "These results indicate that dopamine D4 receptors are activated by noradrenaline and adrenaline, although at 50-100-fold higher concentrations than dopamine.".
How do they calculate the "50-100"? 12.1 / 2.6 is ~ 4.7.
What do these affinities mean at physiological concentrations of these neurotransmitters?
-undopaminergic

Thread

Norepinehprine D4 receptor linkadge 5/28/20
Re: Norepinehprine D4 receptor undopaminergic 5/29/20
Re: Norepinehprine D4 receptor linkadge 5/29/20
Re: Norepinehprine D4 receptor rjlockhart37 5/30/20
Re: Norepinehprine D4 receptor NKP 5/31/20
Re: Norepinehprine D4 receptor » NKP linkadge 5/31/20
Re: Norepinehprine D4 receptor undopaminergic 6/1/20
Re: Norepinehprine D4 receptor » undopaminergic linkadge 6/1/20
Re: Norepinehprine D4 receptor undopaminergic 6/1/20
Re: Norepinehprine D4 receptor » undopaminergic linkadge 6/1/20
Re: Norepinehprine D4 receptor » linkadge undopaminergic 6/2/20

Post a new follow-up

Notify the administrators

Start a new thread

poster:undopaminergic thread:1110375
URL: http://www.dr-bob.org/babble/20200511/msgs/1110387.html

	for
in