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Re: question: why are MAOIs dangerous with stimulants undopaminergic

Posted by linkadge on May 18, 2020, at 8:12:03

In reply to Re: question: why are MAOIs dangerous with stimulants, posted by undopaminergic on May 18, 2020, at 7:07:11

Parnate can have an amphetamine like effect in that it also releases dopamine to some extent. Nardil doesn't have this effect directly, although it does metabolize to PEA which is an endogenous amphetamine. Interestingly inhibiting MAO-B also slows the breakdown of PEA. MAO-B inhibitors can have stimulant like effects in some individuals.

I would argue that MAOIs would give a 'boost' to most people, but that for 'normal' people it might produce some degree of agitation.





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