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Re: question: why are MAOIs dangerous with stimulants

Posted by undopaminergic on May 18, 2020, at 7:07:11

In reply to question: why are MAOIs dangerous with stimulants, posted by cyb3rk4nt on May 18, 2020, at 3:06:00

> Every time I've read the interactions for a drug that acts by either boosting and/or blocking the reuptake of both dopamine and norepinephrine, the biggest warning is to not take it at all within two weeks of taking an MAOI. This has interested me for a while now since I've been on Wellbutrin XL, an SNDRI, for 4 months now and adderall for like 3, (I only take the adderall like twice a week lol). Sorry if the question is dumb but most of the easily accessed info online only warns against it but rarely talks about the actual chemical reaction that would happen if an individual took a stimulant less than 15 days after the MAOI or even worse, took them together!

Amphetamines work like tyramine, releasing noradrenaline from the nerve terminals, and this increases blood pressure on its own, but even more so when MAO is inhibited, because it prevents the breakdown of noradrenaline.

Too much amphetamine taken under MAO inhibition can thus increase the blood pressure to dangerous levels.

That said, amphethamines can, with caution, be combined with MAOIs.





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