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Re: question: why are MAOIs dangerous with stimulants

Posted by alexandra_k on May 18, 2020, at 4:08:25

In reply to question: why are MAOIs dangerous with stimulants, posted by cyb3rk4nt on May 18, 2020, at 3:06:00

there's a metabolic pathway that goes like this.

phenylalanine -> tyrosine -> l-dopa -> dopamine -> norepinepherine -> epinepherine.

neurones signal to one another by releasing norephinepherine into the synaptic cleft. it stays there for a time so other neurones receive the signal. then it mostly gets taken back up by the pre-synaptic neurone.

apparently amphetamines exhibit their effects by preventing re-uptake of norepinepherine. so the norephinepherine hangs about in the cleft for longer so has more of an effect on the neurones downstream.

apparently monoamine oxidase is a substance in the syndaptic cleft that in involved in the removal or norepinepherine (also serotonin and dopamine). so inhibiting an inhibitor would mean that the substance would hang about in the cleft for longer so having more of an effect on the neurones downstream.


in other words...

i would expect them to be somethign of a multiplyer. don't remember the term. would expect the effects of both in combination to be greater than the sum of parts. like benzos + alcohol.

i wouldn't recommend it. that's likely why they say 'dangerous'.




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