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Re: Low-dose buprenorphine (Subutex) for depression undopaminergic

Posted by Hugh on April 8, 2020, at 11:56:23

In reply to Re: Low-dose buprenorphine (Subutex) for depression, posted by undopaminergic on April 8, 2020, at 11:25:27

> As for naltrexone, I am skeptical, because buprenorphine has a long half-life and binds very tight to the opioid receptors. Seems to me they would interfere with one another.

You're right, a typical dose of naltrexone would interfere with buprenorphine. But I'm talking about ultra-low-dose naltrexone at doses in the nanograms or even picograms. These extremely low doses of naltrexone have been found to enhance the effects of opioids, helping to prevent tolerance and withdrawal.

https://www.dr-bob.org/babble/alter/20180212/msgs/1103507.html


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poster:Hugh thread:1109452
URL: http://www.dr-bob.org/babble/20200303/msgs/1109478.html