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Low-dose buprenorphine (Subutex) for depression

Posted by Hugh on April 7, 2020, at 10:45:09

Buprenorphine (Subutex) is an opioid that's used to treat pain and, like methadone, is used to get people off of other opioids. Doses vary from 4-24 mg per day. The average daily dose is 16 mg. Much lower doses of buprenorphine, taken sublingually, significantly decreased depression symptoms in people suffering from treatment-resistant depression. Their average daily dose was 0.4 mg.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6121503/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4157317/


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