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Re: selegine vs parnate

Posted by undopaminergic on January 18, 2020, at 6:55:35

In reply to selegine vs parnate, posted by rjlockhart37 on January 17, 2020, at 18:56:46

I don't have much information to share on the topic.

However, one difference is that selegiline gets metabolised into l-amphetamine and l-methamphetamine, There is an article suggesting tranylcypromine (Parnate) also metabolises to amphetamine, but this has not been confirmed by other studies.

Parnate has an intrinsic amphetamine-like action, whereas selegiline has this effect through the metabolites.

Per milligram, it appears selegiline is more potent.

The l-amphetamines of selegiline can cause cardiovascular effects that tranylcypromine does not have.





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