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Re: What do TRD patients take without an MAIO linkadge

Posted by undopaminergic on December 2, 2019, at 7:10:08

In reply to Re: What do TRD patients take without an MAIO undopaminergic, posted by linkadge on November 30, 2019, at 7:29:07

> With lower doses, you'd be more selectively inhibiting MAO-B. But yes, in theory it could cause serotonin syndrome.
>

Yes, the selectivity is dose dependent. However, this is complicated by the fact that the same dose can have different effects in different people. It also depends on the dose of the serotonergic agent, and the level of serotonin reuptake inhibiton it produces.

> The effect of monoamine oxidase inhibitors can not easily be replicated by monoamine reuptake inhibitors.
>

Agreed.

> [MAOs] break down a number of trace amines, which likely contributes to their unique properties.
>

Yes, some authors have even suggested that MAO-B may be appropriately called "phenylethylaminase". Even so, it did not seem to work for me, and even augmentation with phenylalanine did not produce any noticeable effects for me. I had to take phenylethylamine itself, and that was a powerful intervention, which should be used with care; it is possible to achieve the same kind of adverse and neurotoxic effects as with amphetamines.

-undopaminergic


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