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Re: What do TRD patients take without an MAIO undopaminergic

Posted by linkadge on December 2, 2019, at 9:11:20

In reply to Re: What do TRD patients take without an MAIO linkadge, posted by undopaminergic on December 2, 2019, at 7:10:08

Nice chat,

Amphetamines are not always neurotoxic. In lower dose paradigms (i.e. stroke rehabilitation) they can actually be neurotrophic. I remember reading a study that low dose meth actually enhanced synaptic plasticity and recovery after TBI.

I've never taken selegiline but I often do well by adding the herb FO-TI (purportedly fairly selective towards MAO-B) and it helps quite a bit with energy and focus.

Selegiline can have differential effects on MAOA vs. MAOB in different species (i.e. mice vs. primates). I haven't seen any studies of such variation in humans, but purportedly it can lose it's selectivity towards MAO-B over time, which could lead to interactions.

In my own experience with monoamine reuptake inhibitors and MAOIs, MAOIs produce a much different feel to them. For MAO-A, there are other trace amines (such as tryptamine) whose elevation may enhance the clinical effect as dose psychedelics may have antidepressant effects for some individuals.





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