Posted by Busub on June 16, 2015, at 7:39:24
In reply to Re: Desipramine Questions » busub, posted by SLS on June 16, 2015, at 6:54:30
> > I took my first 25mg last night and while I have a little fatigue (much improved over the clomipramine) I feel restless today.
>
> I am not surprised. I had the same sort of reaction. It went away within a few days. I hope your reaction follows a similar pattern. Desipramine is one of the most potent and selective reuptake inhibitors or norepinephrine, which is known to be an excitatory neurotransmitter. It might be a good idea to stay at 25 mg/day until the restlessness subsides. Are you taking Prozac, Paxil, or Wellbutrin. These drugs can interfere with TCA metabolism, and requires that the dosage of TCA be reduced by approximately 50%.
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> - Scott
Also, would a beta blocker help? Or would it block the effects of desipramine considering its NRI properties.Would nortriptyline have been gentler? I think my pdoc rx'ed desipramine because of its lower SE profile but man this agitation is no fun.
poster:Busub
thread:1079697
URL: http://www.dr-bob.org/babble/20150520/msgs/1079794.html