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Desipramine Questions

Posted by busub on June 12, 2015, at 15:38:17

After a very short failed trial of Latuda (akathisia, muscle pain), I finally convinced my pdoc to do a TCA trial. He had been hesitant based on my previous experience on clomipramine (extreme sedation, constipation and sexual side effects), but relented after I sent him an email on my thoughts on nortriptyline. At the appointment though, he threw me a curve ball and prescribed desipramine instead.

I took my first 25mg last night and while I have a little fatigue (much improved over the clomipramine) I feel restless today. Is this normal for TCA's? I was under the impression that this was less of an issue than with the SSRI's. If this is the TCA, how long can I expect it to last?

Last question, anyone else with experience on desipramine? Any input would be appreciated.


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