Re: Desipramine Questions

Posted by SLS on June 19, 2015, at 13:33:20

In reply to Re: Desipramine Questions » busub, posted by Escapee on June 16, 2015, at 17:31:09

> I see people mentioning nortriptyline but that still is a part SRI part NRI. ie, you can still get serotonin syndrome if mixed with other serotonergics.
It is very possible that I mentioned it. Nortriptyline is heavily weighted towards NE. Compare:
1. Nortriptyline: http://bit.ly/1d6hBke
2. Desipramine: http://bit.ly/1d6ieKD
I take Parnate and nortriptyline together. If nortriptyline were truly serotonergic at therapeutic dosages, I would be suffering from serotonin syndrome. I'm not. Serotonin syndrome is weird, though. You never known when it is going to pop-up.
The immediate anxiolytic properties of nortriptyline might be due to its antagonism of serotonin 5-HT2a receptors. Later, NE downregulation may help with anxiety as well. I don't think serotonin reuptake plays a role here.

- Scott
Some see things as they are and ask why.
I dream of things that never were and ask why not.
- George Bernard Shaw

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