Posted by burial on January 9, 2015, at 8:17:31
In reply to Re: Mutiple mechanism with Zyprexa and some atypicals, posted by Lamdage22 on January 9, 2015, at 3:47:21
> Okay, the options i see now are either replacing Zyprexa with Clozapine (although i wonder if it is any better in the Diabetes department??) or replacing it with amisulpirid (although i heard that some of its side effects occur as frequently as with typical APs!).
>
> Help!
i don't think replacing zyprexa with clozapine is rational, they're quit similar drugs with clozapine having even more nasty side effects like seizures. Amisulpride would be quite different and as effective as any other atypical for whatever it's prescribed. Stahl says it's a dopamine partial agonist, but i couldn't find anything on the internet to support his claim although it definitely has some action on D2 autoreceptors, it was activating for me. There was a huge study not so long ago which ranked every antipsychotic to groups by how effective are they in treating schizophrenia. Guess what, amisulpride was ranked in top tier along with clozapine and olanzapine, a simple typical antipsychotic couldn't perform so strong
poster:burial
thread:1074889
URL: http://www.dr-bob.org/babble/20150102/msgs/1074988.html