Posted by ed_uk2010 on January 7, 2015, at 11:52:51
In reply to Antipsychotics: Diabetes via malnutrition?, posted by Lamdage22 on January 7, 2015, at 5:51:20
> Hey,
>
> my doc said that Seroquel and Zyprexa dont directly cause diabetes but they do so solely via bad nutrition and overweight.
>
> Is this true?
>
>Well, Zyprexa causes diabetes via multiple mechanisms. It's unfortunate... it tends to be one of the most effective antipsychotics apart from clozapine. Seroquel and Risperdal can also cause diabetes, but not as frequently. The reasons behind the diabetes have been studied in humans and animals.
In rats, Zyprexa rapidly and substantially reduces sensitivity to insulin (ie. it induces insulin resistance). Zyprexa also appears to increase output of glucose from the liver, and to reduce insulin secretion via an effect on the pancreas. These effects can lead to substantially elevated blood sugar (glucose). In humans, some patients treated with Zyprexa become insulin-dependent, at least while on treatment.
Another interesting finding in rats is that Zyprexa increases the uptake of fatty acids into adipose tissue (fat deposits). This may promote the accumulation of fatty tissue on the body, especially when coupled with increased appetite/food intake (and/or decreased physical activity).
Diabetic emergencies such as ketoacidosis with confusion and loss of consciousness have occasionally been reported to occur very soon after starting Zyprexa, but the risk increases over time, especially if a large weight gain has occurred. There have been some fatalities due to such emergencies, which I believe have led to legal action against the manufacturer - mainly based on the belief that the prescribing information was (formerly) inadequate.
poster:ed_uk2010
thread:1074889
URL: http://www.dr-bob.org/babble/20150102/msgs/1074912.html