Posted by Scars R. Stories on April 1, 2013, at 17:21:58
In reply to Re: Long-term antidepressant studies, posted by linkadge on March 31, 2013, at 18:22:32
> >Effexor (XR) and Wellbutrin are the ONLY >antidepressants that have been proven to work in >long-term studies.
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> What the hell are you talking about? Seriously. Why are you hell bent on bashing mirtazapine? There have been other "long term" studies on the ability of fluoxetine, mirtazapine, TCAs and sertraline (probably others) to prevent relapse.
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> Also, SSRis alone give me bad anorexia. Adding wellbutrin made this worse for me. Remeron gives me great sleep, and helped improve the apathy caused by effexor.
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> Admit it, high dose effexor + wellbutrin, you might as well be snorting cocaine.
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> Personally, I think mirtazapine is the bomb! I take about 7.5 mg of mirtazapine with effexor and have done great. I tried higher doses of effexor and I just end up agitated with insomnia. I can't concentrate on high doses of effexor either. Also, long term, it just makes me an apathetic zombie.
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> I would agree that mirtazapine has some antipsychotic like effects. It does not have direct antidopaminergic action, however. 5-ht2 antagonism can modulate the dopamine system. 5-ht2 antagonists have some antipsychotic like effects.
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> Longer term, high dose effexor just makes me unstable and paranoid. Effexor greatly supresses rem sleep, which can cause initial euphoria but wicked relapse. I would agree that remeron does not have the same umph as effexor, but in conjunction with other meds, it can help TRD. The combination of effexor and remeron is superior to either agent alone. Infact, remeron + effexor was found superior to parnate for TRD.
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Have you been using cocaine? lolThat is a combination psychiatrists use when they are in the business of saving lives. I never said anything about COMBINING them, though you're going to be disappointed. Most antidepressants in development right now are...
SNDRIs! What must that be like, crack? Especially if you crush your pills up and smoke them? :\ Your comment strikes me as bizarre.
I corrected myself already, I'll do it once more - I meant to say "EFFEXOR AND WELLBUTRIN ARE THE ONLY EFFECTIVE ANTIDEPRESSANTS ***OVER THE PAST 40 YEARS***" ...I'll also fetch the reference. So I did not mean to say anything about TCAs or MAOIs. I stand by my statements about SSRIs and Remeron both lacking any demonstrable therapeutic value in the treatment of depression. Here: Ed Shorter http://www.amazon.com/Before-Prozac-Troubled-Disorders-Psychiatry/dp/0195368746 ....he's quite respected among psy-s.
Fluoxetine has been one of the worst performing SSRIs. Not only does it do nothing for depression, but it's the antidepressant most likely to cause mania/psychosis. And the most likely to cause many other side effects.
Really, do you know anyone who takes PROZAC in this day and age?
Mirtazipine has been proven to be helpful to some with SLEEPING. Hence the counteractiing your "Effexor buzz" bit. Depression? Nope. Not even classified as one in recent psychopharmacological indexes. These books are a little heavy to throw your way, surely you have some of your own?Everyone metabolizes drugs differently. I take a high dose of Effexor because I have an incredibly fast metabolism. I'm sorry. Just call me a cokehead while you're promoting antidepressants that don't work, won't you?
scars
poster:Scars R. Stories
thread:1041418
URL: http://www.dr-bob.org/babble/20130322/msgs/1041497.html