Posted by Bob on March 31, 2013, at 22:11:47
In reply to Re: Long-term antidepressant studies, posted by linkadge on March 31, 2013, at 18:22:32
> >Effexor (XR) and Wellbutrin are the ONLY >antidepressants that have been proven to work in >long-term studies.
>
> What the hell are you talking about? Seriously. Why are you hell bent on bashing mirtazapine? There have been other "long term" studies on the ability of fluoxetine, mirtazapine, TCAs and sertraline (probably others) to prevent relapse.
>
> Also, SSRis alone give me bad anorexia. Adding wellbutrin made this worse for me. Remeron gives me great sleep, and helped improve the apathy caused by effexor.
>
> Admit it, high dose effexor + wellbutrin, you might as well be snorting cocaine.
>
> Personally, I think mirtazapine is the bomb! I take about 7.5 mg of mirtazapine with effexor and have done great. I tried higher doses of effexor and I just end up agitated with insomnia. I can't concentrate on high doses of effexor either. Also, long term, it just makes me an apathetic zombie.
>
> I would agree that mirtazapine has some antipsychotic like effects. It does not have direct antidopaminergic action, however. 5-ht2 antagonism can modulate the dopamine system. 5-ht2 antagonists have some antipsychotic like effects.
>
> Longer term, high dose effexor just makes me unstable and paranoid. Effexor greatly supresses rem sleep, which can cause initial euphoria but wicked relapse. I would agree that remeron does not have the same umph as effexor, but in conjunction with other meds, it can help TRD. The combination of effexor and remeron is superior to either agent alone. Infact, remeron + effexor was found superior to parnate for TRD.
>
Linkadge:I was always under the impression that low dose Remeron is extremely sedating and causes significant weight gain. I assume you might not have a problem with the weight part of it since I think I can recall you actually have problems keeping weight on. If I am correct on that part, what about the sedation? Did you have an initial problem and then it wore off, or did you never have a problem?
Bob
poster:Bob
thread:1041418
URL: http://www.dr-bob.org/babble/20130322/msgs/1041464.html