Psycho-Babble Medication | about biological treatments | Framed
This thread | Show all | Post follow-up | Start new thread | List of forums | Search | FAQ

Re: question, Re: the only way out

Posted by linkadge on April 18, 2011, at 18:38:14

In reply to question, Re: the only way out » SLS, posted by floatingbridge on April 18, 2011, at 17:33:46

Cortisol (stress?) increases the expression of excitory 5-ht2a receptors and decreases the expression of inhibitory 1a receptors. As a result, there is excessive glutamatergic activity in the cerebral / prefrontal corticies.

5-ht2a blocking AD's will reduce some of the enhanced activity at 5-ht2a receptors. But, it might take some time till the receptors actually decrease in expression.

SSRI's take some time to decrease 5-ht2a expression and in the mean time might make anxiety worse by activating these receptors. Combining with a 5-ht2a blocking agent, might have theraputic utlilty by decreasing the effect of the oversensitive receptors untill they decrease in affinity.

Basically, one theory is that its the ballance of 5-ht1a / 2a that is off in heightened anxiety / suicidality especially.


Linkadge


Share
Tweet  

Thread

 

Post a new follow-up

Your message only Include above post


Notify the administrators

They will then review this post with the posting guidelines in mind.

To contact them about something other than this post, please use this form instead.

 

Start a new thread

 
Google
dr-bob.org www
Search options and examples
[amazon] for
in

This thread | Show all | Post follow-up | Start new thread | FAQ
Psycho-Babble Medication | Framed

poster:linkadge thread:983009
URL: http://www.dr-bob.org/babble/20110418/msgs/983186.html