Posted by floatingbridge on April 18, 2011, at 17:33:46
In reply to Re: the only way out » poser938, posted by SLS on April 18, 2011, at 5:52:41
> You are right about cyproheptadine. It is considered an anti-serotonergic that blocks 5-HT2a and 5-HT2b receptors. This in turn increases dopaminergic activity in various regions of the brain, including the prefrontal cortex - an area important for cognition and mood. Interestingly, 5-HT2a receptor binding is increased in suicide victims. This upregulation might indicate a decrease of serotoninergic activity in the PFC. This is in contrast to the mood-lifting properties of antipsychotics that block 5-HT2a receptors.
>Scott, I'm having difficulty parsing this information out and applying to my own situation, one in which AP's (limited experience) make me feel worse.
So a 5-HT2a receptor binding agent is the same way of saying anti-serotegenic agents in the above paragraph? Obviously I'm not following. (It's me.)
And remeron? I haven't tried it. A friend considers it a cornerstone in her sustained recovery.
Thanks
> Linkadge is very capable.
Yes! :D
fb
He is an amazing resource for information. I'm sure he will correct my errors and expand upon what I have said.
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> Have you ever tried Remeron?
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> I'm glad you are now in a more positive and constructive state of mind. This is a heroic effort in view of the frustration and pain you must endure. Keep it up and continue to think creatively.
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> Suicide is a way out for which there is no way back in.
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> There is actually a neurobiology for suicidality. Anger and anxiety make it worse. In other words, there is the possibility that you are currently wired biologically to *feel* suicidal. When this is combined with having to manage a depressing situation, things get dangerous. You might need to start looking at this feeling of suicidality to be artificially produced by a dysfunction brain. Self-talk that recognizes these false fellings might help. It has helped me, especially when I have had bad reactions to medications. I avoid making decisions while in this state.
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> - Scott
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> > i stopped going to one because he said there was nothinng else he could do.. and my new one prescribed me celexa(ssr) which is the 1st thing thats usually tried im sure you know. its the only ssri i havent taken and the other ones numbed me to different extents. ive tried wellbutrin and it has a different numbing effect on me than SSRI's.
> > Well i'll tell you a bit of my psych history.
> > in 2005 when i 1st saw a psych he prescribed me cymbalta and adderall. after about a month my tolerance grew to adderall completely to 20mgs XR so i tried taking 2 of them and i still could not feel it one bit. usually people can up their dose and get and effect but i got nothing. i also ended up with anhedonia/extreme anxiety from that combo.. i suffered for a year and then gave and tried effexor and it made me sooooo NUMB! so i tried adderall again and still got no effect from it at all even tho it had been a year.
> > a few days later i asked my doc for cyproheptadine to help with effexor side effects. so i took it, slowly increasing the dose week for about a month..and then all the sudden my anhedonia had gone away. i could feel adderall again, and i was much less numb... but still pretty numb.
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> > 2 years went by and then i finally went to a medical doc to see if anything could take away all the numbness and thats when i was given mirapex. after a month and a half i ended up with anhedonia from it. thats when i realized adderall had caused my anhedonia in the past. so i tried cyproheptadine again, it helped quite a bit again, but i ended having to take too high a dose of it this time and had to stop taking it, unfortuanately.. and ive slowly gotten worse since i stopped taking it in december 2010. im going to get some more of the cyproheptadine tuesday to see if my tolerance has gone down to it yet. i storngly believe cyproheptadine affects dopamine receptors by upregulating them/ sensitiziing them in some way. and that increases the release of dopamine. i dont get how, im just positive it does.
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> > sorry if some of this sounds unclear, i can seriously not think straight .
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*a rose by any name
poster:floatingbridge
thread:983009
URL: http://www.dr-bob.org/babble/20110418/msgs/983181.html