Posted by Conundrum on December 15, 2010, at 23:49:25
In reply to Re: Looking for some med advice, posted by Hombre on December 15, 2010, at 23:25:51
> Your results will vary, of course, but I find that remeron works with the effexor to increase NE, and I swear Seroquel, despite it's nighttime sedation, adds to the antidepressant effect. It is very similar to remeron in some regards, increasing pre-frontal NE and D through pre-synaptic HT receptor blockade (I forgot all the details, not that it really matters).
>
> Yes, Seroquel does keep me from having racing thoughts, but I believe it is also working on NE and D to some extent. I think with Remeron or Seroquel, you might still need an SNRI to work on the "other end".
>
> I believe zyprexa and seroquel can have an AD effect, and adding them to an AD, maybe an SNRI, could create a more balanced effect if you have any anxiety or soft bipolar symptoms. But it all comes down to what your body responds too, and sometimes you have to wait a while before the effect plateaus and you no longer feel the acute sedation, grogginess, etc.
>
> Anyway, I just wanted to share my combo as an example of something that works, and maybe it can give you and your doc ideas. Even if she doesn't like the idea of adding effexor, too bad. It's one of Stahl's "Heroic Combos" and should be an option should you need some outside the box ideas.Thanks for the advice. Seroquel does increase norepinephrine. I know its metabolite is an NRI, but I dont' know how much of that comes into play in the brain. Are you taking higher dose effexor where there might be a dopamine effect.
Maybe if I can't get any results with the tools she is giving me I should find someone else? Well I know she prescribes seroquel, I've seen the samples in her office. I think I'm gonna go back on prozac and give it a few months. I know it will do something, and maybe building on something that kind of works is better than starting from scratch. I'd be more willing to start from scratch with an MAOI though, since they're supposed to be very powerful.
Now you got me thinking effexor + remeron might be stronger than prozac + remeron. Have you ever tried effexor on its own and did it work for more than a couple weeks?
Also, thanks for offering the list of heroic combos, I've found it online though. Unfortunately a lot of his combos use wellbutrin and stimulants which just don't work for me. Also TCA's are out for now.
Complaints: post-SSRI problems: anhedonia, memory and concentration problems, sexual dysfunction. )
Country:USA
Currently taking SAM-e 1200mgs
poster:Conundrum
thread:973640
URL: http://www.dr-bob.org/babble/20101203/msgs/973686.html