Posted by Conundrum on December 15, 2010, at 22:50:55
In reply to Re: Looking for some med advice, posted by Hombre on December 15, 2010, at 21:36:48
> I went from being a wreck to near remission on Remeron in a week, but it also started to poop out. Combining it with effexor xr seemed to do the trick. I noticed a surge of energy, jitters, and constipation with each dose increase of remeron and/or venlafaxine xr. I assume those were side-effects of increased levels of NE. It would go away after a few days, but overall the energy and interest I seem to get from the combination works for me.
>
> I tried reducing remeron, but I felt a bit flat. I'm not sure what it is doing now, but it seems to work synergistically with the effexor xr. I also take Seroquel, only 100mg, and that also helps brighten things up a bit as well as knocking me out cold every night. I tried reducing it to 50mg, but again felt a bit flat. I definitely need something that affects norepinephrine levels.Well she actually wants me to keep taking remeron, so maybe that would be similar with the prozac? I think the reason it poops out is because 5 HT2 receptor antagonism, is just not a very strong antidepressant mechanism and perhaps the addition of an agonist prevents upregulation or something, idk, i'm tired.
I'd wanted to try that combo too, but she didn't seem to keen on it. Effexor might be better than fluoxetine, which gives me more headaches and pristiq does not, so effexor probably wouldn't either.
Increasing norepinephrine seems to help with motivation. I'm wondering if a bigger bump in dopamine could help with creativity though. I'd like to come up with some good musical ideas again.
Complaints: post-SSRI problems: anhedonia, memory and concentration problems, sexual dysfunction. )
Country:USA
Currently taking SAM-e 1200mgs
poster:Conundrum
thread:973640
URL: http://www.dr-bob.org/babble/20101203/msgs/973683.html