Posted by ggggg123 on October 31, 2010, at 17:49:11
In reply to Re: To Cheryl-Lynne Anhedonia, posted by Conundrum on October 31, 2010, at 17:32:20
Many GPCRs downregulate in response to agonists for the receptor, and upregulate in response to antagonists. The 5-HT2A and 5-HT2C receptors appear to downregulate in response to both antagonists and agonists. Chronic treatment with antipsychotic drugs, which possess 5-HT2 antagonist activity, results in downregulation of both 5-HT2A and 5-HT2C, as does chronic treatment with SSRIs and other 5-HT agonists.[12] However, chronic SSRI treatment may increase 5-HT2C expression, specifically in the choroid plexus.
This is an extract from wikipedia, its a little bit ambiguous and contradictory, but in the end it points out that ssri's may increase 5ht2c expression, which could play a major factor I think in post ssri apathy. If any receptor is responsible for anhedonia it would be this one, this is the one that stops our dopamine and norepinephrine from working. Basically the cure should be a drug which reduces 5ht2c expression or causes downregulation. Maybe a tca or 5htp supplement could be beneficial? or maybe an anti psychotic taken for a long period? how long did you take aripiprazole for?
poster:ggggg123
thread:10100
URL: http://www.dr-bob.org/babble/20101030/msgs/967845.html