Posted by Conundrum on October 31, 2010, at 17:32:20
In reply to Re: To Cheryl-Lynne Anhedonia, posted by ggggg123 on October 31, 2010, at 17:22:55
> >------I agree, I think this is the reason why low dose prozac works so well for me, but a higher dose does not. Prozac is a 5HT2A/C antagonist, most of the studies emphasize its actions as a 5HT2C antagonist more than its effect at the 2A receptor, so I think it may have a stronger effect on the 2C receptors. At a low dose there is an increase in motivation. At a higher dose there is the opposite effect. So i think that antagonism comes into play at the lower dose but the SRI effect isn't too strong. Its there believe, me, there is still sexual dysfunction, for me, even at that low dose. It seems like the antagonism needs an increase in serotonin to have an effect. Perhaps pure antagonism, creates an upregulation in receptors so the effect is lost, but with some agonism by serotonin the receptors are down regulated and some are blocked, leading to increase NE/DA release in the PFC
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> Maybe the upregulation is the reason why we experience worse symptoms when off the drug, as when we go back on the drugs they antagonize the receptors but when we come off they are upregulated, causing anhedonia, maybe a long term strategy using a 5ht2c and a agonist might help return receptor functioning to pre ssri levels. we need a drug that is the opposite to an ssri lol
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> lol just a thought, but there seems to be some reason why symptoms are even worse off the drug.Well I just started taking tianeptine, which is a serotonin reuptake enhancer, so it is an indirect serotonergic antagonist. In the end it may not make a different. Taking an SSRI decreases the number of transporters that bring serotonin back into the cell, tianeptine does the same thing, which would seem to limit its effectiveness overtime. I'm not convinced there is a way to get the brain to function the way it once had. I've been off prozac for 7 years. For of those years I took no drugs, save ginkgo biloba, which is supposed to help the brain. I also took choline precursors and fish oil. My brain never went back to the way it was. I'm not convinced that it is possible. Some people do get back to their previous state, but I'm just not that lucky.
Perhaps I would have ended up in this state without the drugs? Idk.
Complaints: post-SSRI problems: anhedonia, memory and concentration problems, sexual dysfunction. )
Country:USA
Currently taking mirtazapine and tianeptine
poster:Conundrum
thread:10100
URL: http://www.dr-bob.org/babble/20101030/msgs/967841.html