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Re: To Cheryl-Lynne Anhedonia

Posted by ggggg123 on October 31, 2010, at 17:22:55

In reply to Re: To Cheryl-Lynne Anhedonia » ggggg123, posted by Conundrum on October 31, 2010, at 16:34:26

>------I agree, I think this is the reason why low dose prozac works so well for me, but a higher dose does not. Prozac is a 5HT2A/C antagonist, most of the studies emphasize its actions as a 5HT2C antagonist more than its effect at the 2A receptor, so I think it may have a stronger effect on the 2C receptors. At a low dose there is an increase in motivation. At a higher dose there is the opposite effect. So i think that antagonism comes into play at the lower dose but the SRI effect isn't too strong. Its there believe, me, there is still sexual dysfunction, for me, even at that low dose. It seems like the antagonism needs an increase in serotonin to have an effect. Perhaps pure antagonism, creates an upregulation in receptors so the effect is lost, but with some agonism by serotonin the receptors are down regulated and some are blocked, leading to increase NE/DA release in the PFC

Maybe the upregulation is the reason why we experience worse symptoms when off the drug, as when we go back on the drugs they antagonize the receptors but when we come off they are upregulated, causing anhedonia, maybe a long term strategy using a 5ht2c and a agonist might help return receptor functioning to pre ssri levels. we need a drug that is the opposite to an ssri lol

lol just a thought, but there seems to be some reason why symptoms are even worse off the drug.


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URL: http://www.dr-bob.org/babble/20101030/msgs/967837.html