Posted by desolationrower on June 1, 2009, at 1:10:35
In reply to Re: When will Agomelatine be available in the US, posted by Elanor Roosevelt on May 31, 2009, at 21:19:19
> Valdoxan resynchronizes circadian rhythms in animal models of circadian rhythm disruption.??? what does that mean?
probably to do with melatonin. taking melatonin in the evening entrains the body to be tired in the night, and awake during the day.
> Valdoxan increases noradrenaline and dopamine release specifically in the frontal cortex and has no influence on the extracellular levels of serotonin.
due to 5ht2c antagonism
> In humans, Valdoxan has positive phase shifting properties; it induces a phase advance of sleep, body temperature decline and melatonin onset. phase shifting????
geting sleep cycle normal.
-d/r
poster:desolationrower
thread:896778
URL: http://www.dr-bob.org/babble/20090531/msgs/898724.html