Posted by linkadge on June 19, 2008, at 8:16:41
In reply to Re: Possible Eureka., posted by SLS on June 19, 2008, at 5:40:34
>More 5-HT = Less DA?
>Less DA = DA receptor upregulation?
>Could work.
The only problem with the dopamine receptor upregulation is that it is selective to certain deep limbic regions. This is not really consistent with supersensitivity due to a widespread dopamine transmission reduction. Also, if there was a general dopamine reduction, you would expect an upregulation of *all* dopamine receptor subtypes (d1,d2,d3,d4...)
Certain other compounds with AD effect also upregulate d2/d3. Surmontil does, but it has no general effect on monoamine levels. DHEA upregulates d2/d3 receptors but there is nothing I am aware of that says it decreases overall dopamine neurotransmission.
I think I agree with Dave Pierce who suggests that this adaptive process is literally what makes the drug work.
Linkadge
poster:linkadge
thread:835062
URL: http://www.dr-bob.org/babble/20080617/msgs/835423.html