Posted by SLS on June 17, 2008, at 12:49:45
A thought just occurred to me.
Perhaps tianeptine (Stablon) ultimately produces an increase in synaptic concentrations of serotonin via an increase in vesicular stores of this neurotransmitter, and an attendant increase in the amount released as the result of the arrival of an action potential. If the vesicular serotonin transporter is accelerated in the same fashion as the neuronal transporter, the vesicles may become "fatter" and store more serotonin available for each release.
In other words, tianeptine might cause the presynaptic neuron to spit out more neurotransmitter, but only as the result of an action potential.
I am only just now considering the consequences of such an acceleration in the activity of vesicular 5-HT transporter.
One consequence is that tianeptine may not be safe to take in combination with an MAOI.
- Scott
poster:SLS
thread:835062
URL: http://www.dr-bob.org/babble/20080617/msgs/835062.html