Posted by linkadge on June 17, 2008, at 17:43:31
In reply to Re: Possible Eureka. » Phillipa, posted by SLS on June 17, 2008, at 13:23:20
But wouldn't an increase in activity at the serotonin transporter lead to an increase in serotonin break down and metabolism?
SSRI's tend to cerebral spinal fluid levels of serotonin breakdown products, it would be interesting to see how tianeptine affects serotonin metabolites.
There may also be some final regulatory activity on the serotonin transporter. SSRI's initially decrease SERT activity, but some studies suggest long term administration upregulates the transporter.
Most studies on serotonin transporter levels in depression seem to suggest there is a decreased activity of the transporter (midbrain/frontal cortex) perhaps as a compensatory effect of reduced serotonin synthesis and release. It is the same with the NET transporter. When there is a monoamine deficiacny, the brain naturally decreases the level of the transporter to compensate.
Maybe the uptake system naturally oscilates and inhibitors/acellerators simply pull in one direction then let go.
Linkadge
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URL: http://www.dr-bob.org/babble/20080617/msgs/835132.html