Posted by SLS on June 19, 2008, at 5:40:34
In reply to Re: Possible Eureka., posted by linkadge on June 18, 2008, at 21:55:59
> Tianeptine has a sensitizing effect on the d2/d3 receptors like the other TCA antidepressants. This is not generally shared by the SSRIs.
>
> I think there is some other target of these drugs that is far beyond monoamine reuptake.
Or not.My ideas are still not solidified, and I in no way want to express the following as fact:
Tianeptine is not an SSRI. However, it may end up being shown to be a 5-HT amplifier. While the nerve is at rest, the concentration of synaptic 5-HT is decreased. Because of this, the postsynaptic membrane becomes upregulated. When an action potential arrives at the terminal button, a greater amount of 5-HT is released. Tianeptine might act as a 5-HT amplifier that also increases 5-HT tone when the background noise is mitigated. As far as the sensitization of DA receptors is concerned, this is precisely what one would expect from an increase in 5-HT tone along with an increase in the release of 5-HT.
More 5-HT = Less DA?
Less DA = DA receptor upregulation?
Could work.
- Scott
poster:SLS
thread:835062
URL: http://www.dr-bob.org/babble/20080617/msgs/835411.html