Posted by Larry Hoover on May 11, 2008, at 19:45:02
In reply to Re: modafinil and armodafinil, how do they differ?, posted by SLS on May 11, 2008, at 15:34:04
> Thanks, Larry.
You're welcome. I'll be posting my thoughts on your depression/Alzheimer's thread soon.
> I hadn't been aware of these findings. It's nice when some association can be seen between the pure research and the clinical observation.
I also think that the cynical view of "patent extension" may be a low blow when applied without studying the individual case.
> It makes me think that we are not as blind to the inner workings of the black box than we were only a decade ago.
It's still a pretty dark box, if not pure black. But, yes, I'm hopeful that we'll continue to make advances. Certain of it, in fact.
Here are some references for the effects of R-citalopram on S-citalopram binding....
http://www.ncbi.nlm.nih.gov/pubmed/16448580
Shows that R-citalopram reduces s-citalopram binding to SERT (the serotonin transporter).
http://www.ncbi.nlm.nih.gov/pubmed/17235610
Shows that equivalent doses of S-citalopram provided by Lexapro and Celexa produce similar blood concentrations, but significantly reduced SERT binding with Celexa, demonstrating the reduced efficacy of the racemic mixture.
In other words, 10 mg of Lexapro is more effective than 20 mg of Celexa, even though they contain identical amounts of the active principle.
Lar
poster:Larry Hoover
thread:828224
URL: http://www.dr-bob.org/babble/20080510/msgs/828577.html