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Re: modafinil and armodafinil, how do they differ????

Posted by undopaminergic on May 9, 2008, at 19:43:56

In reply to modafinil and armodafinil, how do they differ????, posted by cactus on May 9, 2008, at 17:13:42

> I know they're very similar but what's the exact difference. I'm pretty sure armodafinil isn't available in australia but I'd like to know more about it, can anyone help explain it to me. I'm very happy with my modafinil but I'd just like to know.
>
> I'm asking in here because as soon as I start reading about chemical structures and isotopes etc, my brain just shuts down and shiny objects start getting my attention.
>

Modafinil is a so-called racemic mixture of equal amounts of two optical isomers, R-modafinil (armodafinil) and S-modafinil. See
http://en.wikipedia.org/wiki/Enantiomer

Often a substance is first marketed as the racemic mixture, and then the pharmacologically more active isomer is introduced as a patent-extender, usually with recommended doses that are half of those of the racemate.


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