Posted by undopaminergic on May 7, 2008, at 20:51:23
In reply to Re: Fast acting options for suicidal ideation?, posted by bleauberry on May 7, 2008, at 17:35:36
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> Too much dopamine and/or norepinephrine stuff will make a majority of people very depressed. For example, one of the common consequences of high dose stimulants for some time period is either psychosis or depression.
>
> The other meds are also pumping up dopamine and norepinephrine and that can lead to a very dysphoric depressed lethargic feeling, way beyond the window of feeling energy and joy from dopamine enhancement.
>A depressive state often results from the withdrawal of stimulants - however, that does not seem applicable in this case. It is rather more likely that a pre-existent underlying depression is becoming unmasked as tolerance to stimulants is setting in. Due to tolerance, a functional dopamine deficit can exist even though synaptic concentrations of the neurotransmitter remain normal or elevated above normal. Cessation or dose-reduction will probably aggravate the depressive symptoms initially, but may be necessary to restore responsiveness to the drugs. Alternatively, as has been suggested, memantine can be tried.
poster:undopaminergic
thread:827471
URL: http://www.dr-bob.org/babble/20080430/msgs/827836.html