Posted by alucard on May 6, 2008, at 17:22:37
In reply to Re: A few Cyprenil (liquid selegiline citrate) ?s, posted by undopaminergic on May 5, 2008, at 9:31:23
>the increased metabolism of selegiline when taken on an empty stomach would increase production of the metabolites.
That makes more sense to me too. Bioavailability = absorption of the primary molecule (selegiline in this case), and since breakdown metabolism happens after absorption it only makes sense that starting with more would lead to more, not less, of the end products. Perhaps the article you read stated that the RATIO of selegiline to its metabolites was lower when taken on an empty stomach? So there would be less selegiline RELATIVE to its metabolites when taken with food, but more of both selegiline and the metabolites overall.
Incidentally, with the liquid sublingual form I haven't noticed a difference with vs. without food, so I just take it with as clean a mouth as possible (i.e. I brush my teeth, rinse with water a few times, then wait 5 minutes and put the drops in), same concept as cleaning the skin on an area where you're going to use a dermal patch.
poster:alucard
thread:825078
URL: http://www.dr-bob.org/babble/20080430/msgs/827571.html