Posted by Alucard on May 3, 2008, at 2:56:34
In reply to Re: A few Cyprenil (liquid selegiline citrate) ?s, posted by Amigan on May 3, 2008, at 0:07:03
>Why do you care so much if it's citrate or HCL? Does it even matter?
It might, and it might not. It all depends on what form was used in the animal experiments that have yielded such positive results. The original creators of the citrate form (DEDI) have been rather intense about citrate being the only truly effective form, but quite a few claims they make are pretty seriously sketchy (e.g. nobody else in the WHOLE WORLD knows how to manufacture the citrate form), so I take them with 20 or 30 grains of salt.
>Perhaps they (Cyto-Pharma) don't have a lab equipped to synthesise selegiline, or perhaps they don't have the skills?
Selegiline freebase is extremely easy to make with cheap, readily available chemicals. If you were really determined to do it you could make it at home with chemicals acquired at a reasonable cost from your local hardware store and Wal-Mart, or dirt cheap from the internet. So any laboratory of any size, ESPECIALLY a pharmaceutical lab, would definitely be equipped and skilled enough to make it. Making it at home is a BAD IDEA, however, because your product would be nowhere near 99.99% pure and those little impurities can have a HUGELY negative effect. Pharmaceutical labs in particular are very careful to purify their products extensively for this very reason (one fatal mistake and chances are you're going out of business from the bad publicity and ensuing lawsuits, and possibly facing prison time).
>Since you're a chemist, have you considered trying to make your own selegiline - citrate or otherwise? Aren't you at least tempted to evaporate the water from some of your Cyprenil and determine the melting point of the residue? And perhaps hydrolyse it with a base and see whether you get the oily free base of selegiline? Maybe you even have some contacts within the industry who could help you with HPLC, GCMS, or other advanced methods of analysis?
VERY tempted, and not just selegiline but a whole host of other interesting compounds I've come across throughout the years. BUT I'm kinda wandering around the world with nothing more than I can carry in a backpack at the moment, and will be for the indefinite future. This year I'm in Hawai'i, hence my ability to check this forum every few days, but it'll be awhile before I settle down enough (if I ever do) to put a functional lab together and play around with the molecular world first-hand again. As for analysis of the Cyprenil, I'm honestly very surprised that nobody has published anything along those lines on the internet yet (at least that I've been able to find), especially given all the hullaballoo about citrate vs. hydrochloride. Of course DEDI claims that Cyprenil and Selepryl are both fake, but where is the proof? An independent analysis or two is easy enough to get done as a favor if you're a pharmaceutical distributor (even an EX-pharmaceutical distributor), which they are, and the report would be easy enough to upload if you've got your own website, which they do. Yet as with many of their space cadet claims, they don't bother with irrelevant fluff like...proof. That, to me, is strong evidence that they're full of sh*t.
As for me personally, I'm enjoying the effects of the selegiline I've got, whatever form it may be (I feel like I'm getting my A-game back more and more every day, and it hasn't even been 2 weeks). I ordered some capsules of Mucuna pruriens bean extract to synergize with it and cost-effectively augment its effects (since the bean extract is much cheaper than the selegiline). I've heard good things about the combo, the Mucuna pruriens has a hefty amount of dopamine precursors in it, quite a few neuroprotective compounds, etc. so it sounds like selegiline's perfect other half to me.
Mahalo kids =)
poster:Alucard
thread:825078
URL: http://www.dr-bob.org/babble/20080430/msgs/826954.html