Posted by undopaminergic on May 5, 2008, at 9:31:23
In reply to Re: A few Cyprenil (liquid selegiline citrate) ?s, posted by Amigan on May 5, 2008, at 1:45:03
> > > just make sure to always take them with a meal that's got a decent amount of fat in it because that increases bioavailability by a factor of 3 - 4 times, a huge difference for getting your money's worth.
> > >
> >
> > That does increase the bioavailability of selegiline itself, but it has the opposite effect as far as the metabolites are concerned. The reason why some people find ingestion to be more effective than sublingual absorption may be the metabolism of selegiline to L-methamphetamine and L-amphetamine in the liver. With regard to neuroprotection, the formation of desmethylselegiline is also of relevance.
>
> So, you get more metabolites in your system if you ingest selegiline on an empty stomach? Interesting! I used to think that both the bio-availability of selegiline AND its metabolites increases with food. Thanks for the information!
> I'm one of the few people who finds the oral route to be more effective. I'll try to ingest it without food and see what happens.
>I just tried to verify that my recollection of selegiline pharmacokinetics was correct, but I can't find any references confirming increased bioavailability of the metabolites when selegiline is taken without food; one study suggests that the metabolites are unaffected by coadministration with food, whereas the bioavailability of selegiline is increased. Anyway, it still seems plausible that the increased metabolism of selegiline when taken on an empty stomach would increase production of the metabolites.
poster:undopaminergic
thread:825078
URL: http://www.dr-bob.org/babble/20080430/msgs/827295.html