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Re: A few Cyprenil (liquid selegiline citrate) ?s

Posted by desolationrower on December 19, 2008, at 2:12:26

In reply to Re: A few Cyprenil (liquid selegiline citrate) ?s, posted by karl on December 18, 2008, at 22:16:45

> and if he's going to allow obvious advertisements, people going for the 'mao-b inhibition' in selegiline should know that:
>
> after four days, "inhibition of platelet MAO-B activity is approximately 95% after a daily dose of 2.5 mg selegiline [ORAL, HYDROCHLORIDE], whereas it takes only 48 hours (two doses) for doses of 5 mg and 7.5 mg to achieve this degree of inhibition." [parentheses mine]
>
> source: http://www.ncbi.nlm.nih.gov/pubmed/9853994?ordinalpos=2&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum
>
> any selegiline that reaches the bloodstream is metabolized by the liver into methamphetamine. much more selegiline is ABSORBED into the bloodstream sublingually [under the tongue] than orally [in the stomach, small intestine]. the reason selegiline [any form] is more invigorating under the tongue, therefore, is that MORE of it is metabolized into methamphetamine, and more quickly.

When nutrients are absorbed from the intesting, they go directly to the liver via the portal vein. This is 'first pass metabolism.' Drugs entering otherwise may circulate w/o reaching the liver for a period of time. This is why oral drugs are more extensively metabolised before reaching the brain than otherwise administered drugs.

-d/r

 

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poster:desolationrower thread:825078
URL: http://www.dr-bob.org/babble/20081214/msgs/869578.html