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Re: Amisulpride - and Sulpiride - Selegiline too » undopaminergic

Posted by kingcolon on April 2, 2008, at 14:07:24

In reply to Re: Amisulpride - and Sulpiride - Selegiline too, posted by undopaminergic on April 2, 2008, at 1:32:07

>
> >
> > Do you have a reference to dopaminergic activity of modafinil? I have not seen any literature that suggests it has significant dopaminergic action--it is frequently mentioned that it is nonaddictive because it lacks activity in the mesolimbic system.
> >
>
> Addictiveness is relative, determined by numerous factors. I have no doubt that modafinil can be addictive to certain people under certain circumstances.
>
> The most important feature of modafinil identified so far appears to be its blockade of the dopamine transporter, although it has other properties too.
>
>
> "Modafinil occupies dopamine and norepinephrine transporters in vivo and modulates the transporters and trace amine activity in vitro."
> http://www.ncbi.nlm.nih.gov/pubmed/16885432
>
> "Dopaminergic role in stimulant-induced wakefulness."
> http://www.ncbi.nlm.nih.gov/pubmed/11222668
>
>

Thanks! The 2006 study seems like a good one.


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