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Re: Amisulpride - and Sulpiride - Selegiline too

Posted by kingcolon on March 31, 2008, at 23:37:40

In reply to Re: Amisulpride - and Sulpiride - Selegiline too, posted by undopaminergic on March 23, 2008, at 3:26:22

I propose that methylphenidate and/or modafinil induce cross-tolerance to AMI/SULP. This doesn't particularly surpise me - in fact, at this point I was expecting it. Probably, the mechanism of tolerance is downregulation of post-synaptic dopamine (DA) receptors, which would account for the lack of significance of whether the elevated synaptic DA concentrations were a result of DA transporter blockade (methylphenidate, modafinil) or autoreceptor blockade (AMI, SULP). Alternatively, there is some other neurotransmitter system that becomes upregulated by chronic DA agonism, and has antagonistic effects upon one or more aspects of dopaminergic transmission.

Do you have a reference to dopaminergic activity of modafinil? I have not seen any literature that suggests it has significant dopaminergic action--it is frequently mentioned that it is nonaddictive because it lacks activity in the mesolimbic system.


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