Posted by undopaminergic on March 19, 2008, at 15:48:28
In reply to Re: Amisulpride - and Sulpiride - Selegiline too » undopaminergic, posted by Amigan on March 19, 2008, at 14:16:04
> > I've tried both SULP and AMI, but it's only with the former that I've had the opportunity to experience the "dopamine rush" - a stimulant effect that beats methylphenidate (including high doses) by a wide margin in my experience.
>
>
> That's exactly what i needed to know. No "dopamine rush" with Sulp, while you experienced a notable effect with Ami. Interesting!! Maybe Amisulpride worths its money afterall.You misread me. I tried SULP first, and because I had no tolerance at that point, I experienced the dopamine rush. Later, I acquired AMI mostly for comparison, while I was still taking SULP. Switching from one agent to the other resulted in no remarkable effects, except that I have the faint impression that AMI may be slightly more potent. It will be interesting to see if the DA rush can be reproduced with AMI after some time of abstinence.
The price difference may depend on where you buy the medicines, but if you consider that you need fewer doses of AMI, you may find the difference more modest.
> http://www.dr-bob.org/cgi-bin/pb/mget.pl?post=/babble/20080105/msgs/805921.html#805921
> I know that i suppose to take 50-100mgs of sulpiride, but it starts to feel like an anti-psychotice at this dosage.
>
> This worked well for the first 3 weeks, but know, i feel that i have developed a big tolerence towards to Selegiline.. I don't feel its activating, mood-lifting effect any longer... :( I haven't tried more than 15mg daily.I usually notice the stimulating effects of selegiline for 1-2 days at most, and only after a long time of abstinence. However, selegiline has subtle benefits such as the potentiation of other drugs, and 15% increased life-span or so like the rats Knoll wrote about in one of his articles.
If you want more noticeable effects of selegiline as monotherapy, you need to increase the dose further until the combined effects of MAO-inhibition and amphetamine metabolites become unmistakeable. This style of selegiline-usage has not been well publicised, but would be interesting to learn about.
poster:undopaminergic
thread:816111
URL: http://www.dr-bob.org/babble/20080316/msgs/818843.html