Posted by undopaminergic on April 2, 2008, at 1:32:07
In reply to Re: Amisulpride - and Sulpiride - Selegiline too, posted by kingcolon on March 31, 2008, at 23:37:40
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> Do you have a reference to dopaminergic activity of modafinil? I have not seen any literature that suggests it has significant dopaminergic action--it is frequently mentioned that it is nonaddictive because it lacks activity in the mesolimbic system.
>Addictiveness is relative, determined by numerous factors. I have no doubt that modafinil can be addictive to certain people under certain circumstances.
The most important feature of modafinil identified so far appears to be its blockade of the dopamine transporter, although it has other properties too.
"Modafinil occupies dopamine and norepinephrine transporters in vivo and modulates the transporters and trace amine activity in vitro."
http://www.ncbi.nlm.nih.gov/pubmed/16885432"Dopaminergic role in stimulant-induced wakefulness."
http://www.ncbi.nlm.nih.gov/pubmed/11222668
poster:undopaminergic
thread:816111
URL: http://www.dr-bob.org/babble/20080330/msgs/821111.html