Posted by Quintal on August 21, 2007, at 18:38:09
In reply to Re: SSRIs and bone loss, posted by linkadge on August 21, 2007, at 17:17:17
I remember you saying that SSRIs could cause adrenal fatigue or something like that a while ago, because they increase cortisol release/production? And the HPA axis controls cortisol release/production? I've read that serotonin is the neurotransmitter that modulates stress response, by activating the HPA axis and increasing cortisol. So that is an interesting link. How to explain the differential effects of the secondary-amine TCAs/tertiary-amine TCAs on serotonin though? Secondary-amine TCAs have less affinity for the serotonin transporter don't they? Yet in that study they were associated with a higher incidence of hip fractures than tertiary-amine TCAs, which have greater affinity for the serotonin transporter, if my source is correct.
So what to make of it? Do they have different effects on the HPA axis independent of the serotonin transporter? Or is some other mechanism at play, or more likely a combination of mechanisms.
Q
poster:Quintal
thread:777598
URL: http://www.dr-bob.org/babble/20070815/msgs/777647.html