Posted by linkadge on August 21, 2007, at 20:26:09
In reply to Re: SSRIs and bone loss » linkadge, posted by Quintal on August 21, 2007, at 20:06:51
>How do SSRIs raise cortisol levels?
Not sure. Some, but not all, studies link them to long term elevations in cortisol levels.
>The tertiary-amine TCAs are associated with more >anticholinergic side effects than the secondary->amine TCAs.Yeah, pardon me, I confused the two class names. Perhaps, since the secondary amines are better tollerated, they can be used in higer doses. If some, yet undidentified, dose related factor was at work, then a higher dose might mean something.
For instance, if there was a noradrenergic link to bone loss too, then higher doses, or more relative affinity for norepiniehprine reuptake might be important. (The study lary posted, for instance, said that stress induced bone loss could be prevented by beta adrenergic receptor blockade). So beta adrenergic receptor agonism might be a factor.
Linkadge
poster:linkadge
thread:777598
URL: http://www.dr-bob.org/babble/20070815/msgs/777680.html