Posted by Quintal on August 21, 2007, at 20:06:51
In reply to Re: SSRIs and bone loss, posted by linkadge on August 21, 2007, at 19:37:22
>But the HPA regulating effects of the TCA's are probably unrelated to their effects on monamine uptake. The TCA trimipramine shares with other TCA's the ability to regulate genes responsable for HPA axis regulation, wherase the SSRI's don't have any class effect on the HPA axis.
How do SSRIs raise cortisol levels?
>One wouldn't expect the less anticholinergic tertiary TCA's to produce more falls. I would tend to think that the correlation is not directly related to affinity for the serotonin uptake pump.
The tertiary-amine TCAs are associated with more anticholinergic side effects than the secondary-amine TCAs.
>Perhaps, because the tertiary amines are better tollerated, they can be used in higher doses?
The tertiary-amine TCAs amitriptyline, imipramine etc. are the lest well tolerated out of the three antidepressant groups.
Q
poster:Quintal
thread:777598
URL: http://www.dr-bob.org/babble/20070815/msgs/777674.html